CO2 and HPA have the same fittings and same infrastructure requirements. As long as your regulators aren't shit, you should be able to run CO2 and Nitro.
I have 4 CO2 tanks and 1 HPA tank. The HPA tank is for when it is cold, and even then, only until it gets up around 60 or so.
The idea is that you run the primary regulator really high, like 200-250 PSI, and then fine tune your line pressure with your secondary regulator, down to about 120 (steel Escort guns), 100 (brass Escort guns), 80 (BVs), or 40-70 (Tanaka/KJW gas bolt guns).